Manjushri Bodhisattva expounds upon,
The Holy Truth of Suffering,
The Holy Truth of the Accumulation of Suffering,
The Holy Truth of the Extinction of Suffering,
And, the Holy Truth of the Way Leading to the Extinction of Suffering.
The Four Holy Truths can be called by countless other names in other worlds throughout the ten directions.

Annotation
Most human beings are able to relate to this chapter of the Sutra. One does not need to open the Five Eyes to see ‘The Holy (Noble) Truth of Suffering.’
Buddhism is very practical. It addresses everyone’s immediate problems. Few  can deny that life is full of suffering. Few enjoy suffering. Most wish their sufferings would cease. The First Holy Truth also means unsatisfactoriness. Some people may think that Buddhism is rather pessimistic or negative. On the contrary, the Buddhadharma is very realistic and enriching. Its aim is to edify man.
Some may insist that  there are also moments of pleasure and happiness too.
Worldly happiness is actually suffering in disguise. Kahlil Gibran realized that when he wrote,
When you are joyous,
Look deep into your heart
And you shall find it is only
That which has given you sorrow
That is giving you joy.
When you are sorrowful,
Look again in your heart
And you shall see that
In truth you are weeping for
That which has been your delight.

Life is suffering because life is impermanent. Prince Siddhartha had everything a person could wish for in terms of worldly wealth and power. He was destined to be a King. Throughout the seasons, the Prince was surrounded by beautiful women, beautiful scenery and a variety of delicious food. He was dwelling in an earthly paradise. For many years he lived in such lovely and heavenly surroundings. But later, he realized that all those who are dear to him, including himself and all living beings will someday pass away. Realizing the Holy Truth of Suffering, he made the heroic decision of renouncing his wonderful kingdom in order to find a way out of this boundless mass of suffering. Prince Siddhartha was not confused by royal comfort because he had the wisdom to see the impermanence of everything in this world. Prince Siddhartha said,
“This, namely, that I characterize the round of life as a play, which, with consciousness as machine and the feelings as the actors produces its various scenes… There enter upon the stage craving and fond affection and hundreds of deep-seated lusts. From an infinite time past this play goes on, deceiving, entangling and destroying. There is no man, no body of men, who has not been beguiled and deceived by the compounded elements of personality, and so it was among our forebears. So father, lift up your heart, for I shall end this play of recurrent life, and I shall enter the citadel of calm, of Nirvana, which old age and death do not assail.
“My heart is fixed and though I may not yet attain my end till after long and wearisome discipline, yet I will never return to the pleasures of the world or immerse myself in the pollutions of sensual indulgences. For what happiness can a pure-hearted man find in these? There is no room, therefore, for further parley about returning home. I would rather enter a burning furnace, or a lake of fire, than give up my aim and go back.
“As for the common opinion, ‘pleasures are enjoyable,’ none of them when examined are worthy of being enjoyed; fine garments and the rest are only the accessories of life, they are to be regarded as merely the remedies for relieving pain. Water is desired for allaying thirst, food in the same way for removing hunger, a house for keeping off the wind, heat of the sun and the rain, and clothes for keeping off the cold and covering one’s nakedness. So too, a bed is for removing drowsiness, a carriage for remedying the fatigue of a journey, a seat for alleviating the pain of standing, so bathing as a means for cleanliness, health and strength.
“External objects therefore are to human beings the means for remedying pain, not in themselves the sources of enjoyment; what wise man would allow that he enjoys these delights which are only used as remedies? He who when burned with the heat of a bilious fever, maintains that cool appliances are an enjoyment, when he is only engaged in alleviating pain? Since variableness is found in all pleasures, I cannot apply to them the name of enjoyment; the very condition which mark pleasure, also bring, in turn, pain….”
“When I see how the nature of pleasure and pain are mixed; I consider royalty and slavery as the same.”

• Splendor of Enlightenment

Before one can be convinced to cultivate the Way, one has to truly recognize all the many forms of suffering; that worldly bliss is in reality also suffering because it is impermanent.  Bertrand Russell wrote,
“All our affections are at the mercy of death, which may strike down those whom we love at any moment… It is necessary that our lives should not have that narrow intensity which puts the whole meaning and purpose of our life at the mercy of accident.’
The Buddha says,
‘The whole world is in flames. By what fire is it kindled? By the fire of lust, hatred and delusion; by the fire of birth, old age, death, sorrow, lamentation, pain, grief and despair is it kindled…
‘The bones of a single person wandering in samsara (the world in which we live) would be a cairn, a pile, a heap as Mount Vepulla, were there a collector of these bones and were the collections not destroyed.
‘Long time have you suffered the death of father and mother, of sons, daughters, brothers and sisters, and while you were thus suffering, you have verily shed tears upon this long way, more than there is water in the four oceans.
‘Long time did your blood flow by the loss of your heads when you were born as oxen, buffaloes, rams, goats, etc. Long time have you been caught as dacoits or highwaymen or adulterers, and through your being beheaded, verily more blood has flowed upon this long way than there is water in the four oceans.
‘And thus have you for long time undergone misfortune, and filled the graveyards full, verily long enough to be dissatisfied with every form of existence; long enough to turn away and free yourself from them all.’
It is said,
Know suffering
Cut off Accumulation
Aspire toward Extinction
Cultivate the Way.

The Tripitaka Master Hsuan Hua explains that the Buddha spoke the Three Turnings of the Four Holy Truths:
I.  1.   This is suffering; its nature is oppression.
2.   This is accumulation; its nature is enticement.
3.   This is the Way; its nature can be cultivated.
4.   This is extinction; its nature can be certified to.
II.  1.  This is suffering; you should understand it.
2   This is accumulation; you should cut it off.
3.  This is the Way; you should cultivate it.
4.  This is extinction; you should certify to it.
III. 1.  This is suffering;  I already understand it, and I don’t need to
know anymore about it.

• This is accumulation; I have already cut it off, and don’t need to  further cut it off.
• This is the Way; I have already cultivated it and I don’t need to cultivate it more.
• This is extinction; I have already certified to it and I don’t need to further certify to it.

The Buddha spoke Dharma for over forty years to different classes of people by employing different expedient methods. However, one could say that they were all variations based on the same theme. They were simple, profound, subtle, direct, silent, extensive, and ultimate Teachings on the Four Holy Truths. For instance, one could use the Four Holy Truths to explain why the Bodhisattva cultivates the Way:

• He contemplates the Holy Truth of suffering.
• He contemplates the Holy Truth of the causes of living beings’ suffering.
• He contemplates the Bodhisattva Way.
• He contemplates the Holy Truth regarding the end of suffering and vows to enable all living beings to attain ultimate bliss.

In the chapter on ‘Leaving the World,’of the Avatamsaka Sutra, it explains very clearly that the Great Bodhisattva (Prince Siddhartha) manifests leaving the home-life to cause living beings to renounce their attachments and cultivate the Path of transcending the world. It is to enable living beings to recognize the cause of suffering and cultivate the Way.